English 
简体中文 Cenobamate
1) The main possible mechanism: It reduces repetitive neuronal firing by inhibiting voltage-gated sodium currents, and also acts as a positive allosteric modulator of the γ-aminobutyric acid (GABAA) ion channel.
2) Drug Half-life: 50~60 h.
3) Therapeutic indications: Focal Seizures.
4) Warning: Familial Short QT Syndrome.
5) Administration: May be taken alone or with food.
6) Dosage for children: Click to view the dosage for children of different ages and weights.
7) Major adverse reactions in children: The most common adverse events are dose-dependent somnolence, dizziness, headache, fatigue, and diplopia. Other potential adverse reactions include QT interval shortening, suicidal behavior and ideation, and hepatic injury; multi-organ hypersensitivity reactions have been reported rarely.
8) Interaction with other anti-epileptic drugs: Cinoxate may increase the plasma concentrations of phenytoin and phenobarbital, while decreasing the plasma concentration of carbamazepine. Phenytoin may decrease the plasma concentration of cinoxate.
9) Interaction with non-anti-epileptic drugs: It may decrease the plasma concentration of midazolam. It may increase the plasma concentration of omeprazole.
